The event runs from 12-5 p.m. at the state police post, 714 Old U.S. 27 North in Marshall.
Officials said there are 314 unsolved, unidentified remains cases statewide. The DNA will be used to help with the identification of unidentified remains housed at medical examiners offices throughout Michigan.
Potential donors must be biological relatives and will be asked to allow a non-invasive swab of the inside of their cheek.
Family members are encouraged to bring photographs, dental and medical records, or other identifying information to update law enforcement databases. Personal items will be immediately returned.